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For Healthcare Providers Frequently Asked Questions
Click here to find more about how Malaysia is distributing PAXLOVID to patients
Understanding the science behind PAXLOVIDThe first approved protease inhibitor designed to treat COVID-19 from home.1,2See PAXLOVID in action

PAXLOVID's active pharmaceutical ingredient is nirmatrelvir, an oral protease inhibitor specifically designed by Pfizer to inhibit the main protease (Mpro), also known as 3CL protease, and to help halt SARS-CoV-2 replication by preventing proteolysis from occurring.1,3

  • PAXLOVID also contains ritonavir, a CYP3A inhibitor that is widely used as a pharmacokinetic enhancer1
How PAXLOVID works1. Proteolysis​​​​​​​

In the SARS-CoV-2 life cycle, proteolysis involves the cleavage of viral polyprotein chains by proteases to release the nonstructural proteins that are essential for viral replication.3

2. Mpro

Due to its essential function in viral replication, mutations that occur to Mpro can be lethal to the virus.4

3. Nirmatrelvir

Inhibition of Mpro by nirmatrelvir prevents proteolysis, helping to halt the viral replication cycle.1,3

The role of ritonavir1

Ritonavir is administered with nirmatrelvir as a pharmacokinetic (PK) enhancer, resulting in higher systemic concentrations of
nirmatrelvir and helping to support twice-daily dosing.1,2

  • Ritonavir has a well-characterized safety profile and is used in combination with other antivirals as a PK enhancer1,2,5
EXPLORE MOREDosing

Learn about the oral treatment schedule, dose adjustments, and drug interactions.

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References: 1.  Pfizer Malaysia PAXLOVID™ Prescribing Information, 29 September 2022  https://labeling.pfizer.com/ShowLabeling.aspx?id=17725. Assessed on 13th October 2022 . 2. Owen DR, Allerton CMN, Anderson AS, et al. An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19. Science. 2021;374(6575):1586-1593. 3. Senger MR, Evangelista TCS, Dantas RF, et al. COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Mem Inst Oswaldo Cruz. 2020;115:e200254. 4. Goyal B, Goyal D. Targeting the dimerization of the main protease of coronavirus: a potential broad-spectrum therapeutic strategy. ACS Comb Sci. 2020;22(6):297-305. 5. NORVIR Summary of Product Characteristics. www.ema.europa.eu/documents/product-information/norvir-epar-product-information_en.pdf (Accessed March 2022).
PP-PAX-MYS-0108 13 October 2022

Adverse events should be reported. Reporting forms and information can be found at https://paxaes.pfizersafetyreporting.com

 

For medical questions related to PAXLOVID, you can visit  www.pfizer.com

PfizerPro AccountPfizerPro Account

To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.

This site is intended only for healthcare professionals resident in to Malaysia. 

 

This website is brought to you by Pfizer Malaysia 

 

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PP-PAX-MYS-0108 13 October 2022
For Malaysia Healthcare Professionals

These pages are not intended for patients or for members of the general public.

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